Studies on effect of piperine on oral bioavailability of ampicillin and norfloxacin.

نویسندگان

  • Kunchithapatham Janakiraman
  • Rajappan Manavalan
چکیده

Ampicillin and Norfloxacin are used to treat variety of bacterial infections. These two drugs have low oral bioavailability. Co-administration of Piperine (20 mg/kg), an alkaloid from Piper nigrum L. enhanced oral bioavailability of Ampicillin and Norfloxacin in animal model. This is reflected in various pharmacokinetic measurements like Cmax, Tmax, AUC and t(1/2) of the above antibiotics in animal model.

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عنوان ژورنال:
  • African journal of traditional, complementary, and alternative medicines : AJTCAM

دوره 5 3  شماره 

صفحات  -

تاریخ انتشار 2008